| 1. BackgroundAs well known, dyslipidemia is one of the major changeable coronary artery disease (CAD) risk factors. Lipid-regulating therapy has reduced CAD morbidity and mortality, changed CAD course, prevented formattingatheromatosis, postponed progressing of shaped disease, or even inversed it. L-TAP Study showed lipid in patients of hypercholesterolaemia wasn't controlled very well in China. It is reported that atorvastatin is superior to the other statins, but the related study is scarce in our country. Therefore, it is interesting to evaluate the efficacy and safety of atorvastatin in treatment of primary hypercholesterolaemia, to compare atorvastatin to simvastatin. Then, we can provide objective bases for atorvastatin and simvastatin in clinical.2.Materials and Methods:94 patients of primary hypercholesterolaemia were equably divided into two groups: One group took lOmg atorvastatin (Lipitor) orally once at night. 1 7 of them were males ,30 of them were females, mean age was 58.51 ?.00 years old, mean body weight was 61.32 + 6.39 kilogram, body weight index was 34.45 + 1.15 kg/m2. The other group took lOmg simvastatin orally once at night, 14 of them were males, 33 of them were females, mean age was 56.38 + 6.35 years old ,mean body weight 61.52 + 6.52 kg, body weight index was 34.47 + 1.18 kg/m2. There was no difference between the two groups (P>0.05). This was a randomized x parallel trial. Total cholesterol (TC)^low density lipoprotein cholesterol ( LDL-C)> atherosclerosis index (Ar)ariglyceride(TG)>high densitylipoprotein cholesterol (HDL-C) and LDL-C/HDL-C were obtained. And blood pressure> heart rate> blood routine> urine routine, hepatorenal function > fasting blood sugar, creatine phosphokinase (CPK) were acquired. The chief complaint had been noticed. All data were managed by SPSS 8.0. Metric data were expressed as mean盨D. Statistical methods include Independent-Sample T Test, One-Way ANOVA, Ridit Analysis, and Test of ratio of two samples. Count data were managed by X2 Test.3. Results and Discussion:After treatment for 4 or 8 weeks, TC decreased greatly in the atorvastatin and simvastatin group (atorvastatin group: 4.96 + 1.13mmol/L,4,90 + 1.02mmol/L VS 6.98 ?0.97mmol/L, P<0.01)(simvastatin group:5.09 + 0.86mmol/L,4.96 ?0.72mmol/L VS 6.85 ?0.65mmol/L, PO.01). After treatment for 4 or 8 weeks, LDL-C decreased greatly in the atorvastatin and simvastatin group(atorvastatin group:2.44 ?1.16mmol/L,2.49 ?0.98mmol/L VS 4.40?.04mmol/L, PO.01) (simvastatin group:2.80 + 0.76mmol/L,2.69 ?.72mmol/L VS 4.39?.70mmol/L, P<0.01). After treatment for 4 or 8 weeks, Ar decreased greatly in the atorvastatin and simvastatin group (atorvastatin group: 2.00 ?1.05, 2.01 ?0.98 VS 3.47 ?1.15, P<0.01)(simvastatin group:2.56 ?0.80,2.47 ?0.79 VS 3.97 ?1.33,P<0.01). After treatment for 4 or 8 weeks, LDL-C/HDL-C decreased greatly in the atorvastatin and simvastatin group (atorvastatin group: 1.51 + 0.91,1.56 + 0.86 VS 3.08+1.00, P<0.01)(simvastatin group:1.95 + 0.59,1.88 + 0.61 VS 3.12 + 1.00,P<0.01). TG decreased after treatment for 4 weeks in the atorvastatin group and after treatment for 4 or 8 weeks in the simvastatin group (atorvastatin group: 1.75 + 0.88mmol/L VS 2.12 + 0.83mmol/L,P<0.05) (simvastatin group:!.78 + 0.79mmol/L,1.74 + 0.91mmol/L VS 2.20 + 0.96mmol/L, P<0.05), but TG decreased greatly after treatment for 8 weeks in the atorvastatin group(1.62 + 0.74mmol/L VS 2.12 + 0.83mmol/L , P<0.01). HDL-C hasn't difference after 4 or 8 weeks in the two groups (atorvastatin group: 1.75 + 0.38mmol/L,1.68 + 0.28mmol/L VS 1.63 + 0.32mmol/L , P>0.05) (simvastatin group: 1.49 ?0.35mmol/L,1.48 + 0.31mmol/L VS 1.46 ?0.36mmol/L,P>0.05).In each group,there was no difference after 4 weeks than after 8 weeks (P>0.05). The basic level had no differences each other in the two groups (P>0.05).The above results showed that TC, LDL-C, Ar, LDL-C/HDL-C diddecrease after 4 or 8 weeks in the two groups. These were indexes of atherosclerosis. Not only can atorvastatin and simvast...
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