The Correlativity Of Prefrontal Cognitive Dysfunction With Auditory Event-related Potential In Nondemented And Nondepressed Parkinson's Disease

Objective:This study was designed to evaluated the correctivity of prefrontal cognitive dysfunction with auditory event-related potential in nondemented and non-depressed Parkinson's disease. Methods:Auditory oddball paradigm was employed to evoke event-related potentials(P300) in 31 nondemented and non-depressed patients with Parkinson's disease(PD),and in 25 normal subjects well matched for age ,sex,and education. Three tests:Verbal Fluency,Trail Making and Stroop word-color Test,which are considered to sensitive to prefrontal cognitive dysfunction,was examined in them at the same time. Results:Parkinsonian patients had longer latency of event-related potitial(ERP) than normal subjects,while the prefrontal cognitive state was found deteriorated in PD. ERP changes were correlated with the cognitive state. PD with the lowest scores on prefrontal neuropsychological tests such as Stroop word-color test,Trail making,Word Fluency also had the longest P300 latency.Conclutions:Our results demonstrate the prefrontal cognitive dysfounction in PD with nondemential and nondepression;the correctivity of prolongation of P300 latency with prefrontal cognitive dysfuntion may indicate abnormal P300 latency represent a predictivemarker of this deterioration.