The Experimental And Theoretical Study On Alcoholic Fatty Liver By Zhugezhiganxiao Granule (ZGZGXG)

Alcoholic fatty liver(AFL)is due to the accumulation of fat which results from the alcohol indulgence. Because of the rapid global economic development and the changing of life style, the volume of alcohol intake is becoming more and more, accordingly, the number of the patients who are suffering the AFL increased. This disease is one of the major causes which do harm to the health of human being, and gains more attention. In the guidance of the theory of TCM, referring the recent and past material about the knowledge of alcoholic fatty liver, associated with the modern study of TCM, this article explored the causes and pathogenesis of AFL, curative effect, mechanism of ZGZGXG treating AFL are researched systematically. It's considered that AFL is due to alcohol and oily food indulgence mostly, it's also related to inherent spleen deficiency, emotional disorder, which result in dysfunction of spleen, then the liver lost the function of free coursing. The dampness and turbid are accumulated in the liver. The treatment method is invigorating spleen and smoothing liver Qi, clearing the dampness and turbid. ZGZGXG was composed by the above principle and pathogenesis. It's a effective formula to treat the spleen deficiency and liver Qi stagnation, production of dampness and turbid type AFL. Experimental research indicated :ZGZGXG can treat the AFL of rats in the liver, improve liver function, resist the oxidation, descend the content of oxyproling hydroxyproling and improve the.blood rheology.