Liquid Therapy In Severe Neurosurgical Patients

[Objective] This paper analysed the correlations between infusion quantity and treatment outcome, and other factors, which might affect the correlations. Statistical results were compared with the domestic and oversea views. The best amount and principle of infusion were investigated.[Patients and Methods] Ten factors, including age, sex, therapy mode, diagnosis, condition at admission, daily and average amount of infusion in first 3 days, treatment outcome, were analysed by pearson correlation and Multiple logistic regression in 605 severe neurosurgical patients. Statistical results were discussed on the basis of neurological and neurosurgical principles.[Results] There was positive correlation between treatment outcome and the amount of 3rd 24-hour infusion, and under some condition there waspositive correlation between treatment outcome and the amount of 2nd 24-hour infusion. It indicated the increasing amount of 3rd 24-hour infusion was related to better treatment outcome. There was no correlation between treatment outcome and the amount of 1st infusion or average amount of infusion within first 3 days. It indicated the more amount of 1st infusion or total amount of infusion did not negatively affect the treatment outcome.[Conclusions] It is vital for severe neurosurgical patients to keep normovolemia. It suggests that the amount of infusion should be increased since the 2nd day after the operation or admission, and that the best daily amount of infusion should be above 3000~3500ml under conditions of fasting and mannitol dehydration.