Pregnancy-Associated Plasma Protein A,C-Reactive Protein,Interlukin-6 And Acute Coronary Sydrome

Background Patient with acute coronary syndromes are at considerable risk for serious complications and death. Clinical outcomes might be improved by rapid and accurate diagnosis,followed by appropriate therapy. Now most think that acute coronary syndromes are relationship with rupture of unstable plaques. Circulating markers indicating the instability of atherosclerotic plaques could have dignostic value in unstable angina or acute myocardial infarction. But which markers are helpful in acute coronary events are not vertified. The order of this study is to disscusse whether Pregnancy - Associated Plasma Protein A(PAPP - A),C - Reactive Protein( CRP) , Interlukin -6(IL -6) are the markers of unstable plaques.Methods We measured circulating levels of PAPP - A, CRP and IL - 6 in 20 patients with acute myocardial infarction, 25 with unstable angina, 21 with stable angina,and 15 controls.Results Circulating PAPP - A,CRP JL - 6 levels were significantly higher in patients with acute myocardial infarction or unstable angina than in patients with stable angina and controls. PAPP - A levels correlated with levels of CRP and IL - 6, but not with markers of myocardial injury (troponin I and the MB isoform of creatine kinase).ConclusionsPAPP - A,CRP,IL-6 are present in unstable plaques,and circulating levels are elevated in acute coronary syndromes; these increased levels may reflect the instability of atherosclerotic plaques. PAPP - A,CRP and IL -6 are new candicate markers of unstable angina and acute myocardial infarction.