The Study Of Usual Drug-Breaking Medicines's Effect On Kindling Models

So far,the commonly usual drug-breaking medicines are scopolamine,clonidine and naloxone.As a kind of cholinoceptor blocking drugs, scopolamine can combine with the cholinoceptor but show no or little cholinomimetic actions by itself, however,it can block the combination of cholino-nerve or cholinoceptor agonizing drugs and show anti-cholinoceptic actions. Scopolamine is similar to M-R blocking drugs (atropine),but its action on central nervous system (CNS) is different from that of atropine because it can inhibit the function of CNS as to show significant sedation and hypnosis. Many native and foreign scholars have done much research work on its actions on CNS during the past several years,especially on study,memory and drug-addiction. This article discussed its effect on several kindling models and studied its acting mechanism,results were as following.1 Amygdala and lidocaine kindling models were established successfully.2 Scopolamine 0.5-2.5 mg-kg-1 ip could dose-dependently inhibit the seizure of kindling rats (P<0.05), Scopolamine at the dose above 2 mg-kg-1, showed the repressive effect on kindling (P<0.05).3 When combined with phenobarbital at an ineffective dose 50 mg-kg-1 ip, scopolamine 0.5mg.kg-1 ip can reduce Racine's stage (P<0.05).4 In electricity-stroke model of mice, scopolamine 2.0mg-kg-1 ip could reduce the ratio of seizure and death rate (P<0.05).These results suggested that scopolamine inhibited the seizureof the amygdala kindling and had synergic effect with phenobarbital. The above research may be useful for exploring scopolamine's pharmacological mechanism and its administration in treating epilepsy and drug-addiction.