The Expression And Clinical Significance Of CD105 In Colorectal Cancer

OBJECTIVE: To determine the expression of CD105 in colorectal cancer and the correlation between neoplasm-related angiogenesis (NRA) and the clinical and the pathological factors of neoplasm. To investigate the correlation between angiogenesis and the growth, metastasis and prognosis of neoplasm by detecting the microvessel density (MVD) of colorectal cancer. And the more important thing is that it give us a new idea in anticancer treatment by inhibiting the angiogenesis. METHODS: 48 cases of colorectal cancer tissue and 48 cases of normal control colorectal tissue were investigated by immunohistochemical stain. We detected MVD by markers GDI05 and Factor-VI, and we also examined the VEGF expression. The data were statisticly analyzed. RESULTS: (1) The MVD was found to be significantly higher in colorectal cancer tissue than in the normal control tissue (P<0.001). (2) MVD of colorectal cancer was significantly higher counting by CD 105 staining than by Factor-V! staining (P<0.001). (3) MVD stained by CD105 and the VEGF expression were closely associated with lymphoglandula metastasis, distant metastasis and the clinical Dukes stages (P<0.001), but MVD stained by Factor- Vffl had no relationship with lymphoglandula metastasis, distant metastasis and Dukes stages (P>0.05). (4) there was a significant correlation between CD105 MVD and VEGF positivity (P<0.001), but VEGF expression has no correlation with Factor-Vffl MVD (P>0.05). CONCLUSION: (1) Angiogenesis is associated with neoplasm growth, metastasis and prognosis. (2)Different vascular endothelial cells have different characters, CD 105 is better than Factor-VI in staining new born neoplasm-related microvessels. CD 105 may play the role as a new marker of blood vessels, especially the neoplasm-related microvessels. (3) VEGF plays a crucial role in angiogenesis in colorectal cancer. VEGF expression is associated with neoplasm growth, metastasis and prognosis, and it is also closely correlated with GDI 05 MVD, so MVD can be used as an independent prognostic marker in colorectal cancer.