| The three endocrine axes change as male grow aged. (1) Hypothalamus-Hypophysis- Testosterone axis, the level of testosteone drops as well as the LH and FSH elevate. (2) Hypothalamus- Hypophysis-Adrenal axis, the DHEA and DHEA-Sulfate secrete less. (3)CH-IGF-1 axis, the GH's level decrease and synptomes appear as the Adult GH deficiency Syndrome. However, the clinic nowdays do not find out the methods to detect the endocrine axes changes, therefore, it is difficult to diagnosis and treat the symptoms followed by the endocrine changes. Compairing the female menopause has the exact definitions, the male endocrine changes gradually and variably. And parts of hormone, such as the testosterone, DHEA, DHEA-S, GH, IGF-1 and melatonin become less.The PADAM, Partial Androgen Deficiency in the Aging Male, is referred as the symptoms followed the decreased level of testostrone, mostly after 50 years old. The incidence rate becomes more as the male growes older. The Erectile Dysfunction is defined as the varied decline of erectile function. One survey demonstrated that the incidence rate of ED in male from 40 years to 70 is about 52%, and so ED is commom to the aged male.The growth hormone (GH) is secreted by the somatin cell in the glandular pituitary and composed by 191 amino acid residues. The GH can accelerate the metabolism and promote growth by affect many organs and tissue, especially to the bone, muscle and viscera organs. In details, GH promote the osteoblast, accelerate the synthesis of protein and oxidation of lipid, as well as result in a comparative high level of blood glucose. Recent studies showed that GH could develop erectile function by stimulation the synthesis of endothelial derived NO. In the erectile state, the concentration of GH both in the circulation and the cavernosum becomes obviously high. Another study indicted that the GH could promote the quantity of NO-containing neuron in the pelvic ganglia, and moreover, GH promote the regeneration of nerve fiber derived from neuron. The recombinant human growth hormone (rhGH) is the product of gene engineering project, transferred the GH gene into animal cell by the recombinant DNA technique. It is of high purity and activity, and can be provided endless, at least in theory.This study aims in the efficacy and safety of recombinant human growth hormone (rhGH) for improvements at symptoms in male menopause and impaired sexual dysfunction, by testing the IGF-1 using the ELISA method, and chosing the HEF and Istanbul Bosphorus's Instrument for estimate the male andropause and aging. Moreover, we try to evaluate the specifity and sensitivity of IGF-1 as a marker to detect the male age and direct the GH supply treatmentMATERIALS AND METHODSWe collect 20 patients in the Urological and Andrological clinic of the first affiliated hospital of Zhejiang University, medical college with the chief complaints of suffering from ED or (and) male andropause symptoms as well as 20 normal males younger than 40 years old.The patients would be prepared for 4 weeks to collecting the datas about the Adropause and sexual disfunction as the baseline levels. After the labotory examinations, we choose the prompt volunteers as the cases, and devide them into group A and B by random. In group A, the patients would accept the rhGH injectiuon once a week as well as sodium solution once. In group B, they would receive two times injection of rhGH a week. Every four weeks since the study, we would ask the cases about the improvements in andropause and sexual function with the the IIEF and Male Andropause Self-estimate Tablet. The injection would last for 12 weeks till the repeated examinations, including the IGF-1 of the normalcases and the patients.All the datas will be treated by the statistic SPSS 11.0. The Paired T test will be applied in the IIEF total points and partial points as well as the Male Andropause Self-estimate Tablet. The labotary examinations before and after the study will be processed as the IIEF points. The IGF-1 levels will be analyzed by...
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