| Purpose: To observe the influence of simple obesity on ciuculatory system in early-stage of obese children and to identify the related factors of childhood obesity.Methods: The study involved 73 school-age obese children with mild and moderate and severe obesity and 23healthy children. The obese children group were matched forage, sex and height with a healthy normal-weight control group. Serum lipids were assayed. Blood pressure was determined by Riva-Rocci sphygmomanometer. The left ventricular geometry and function was measured by Doppler ultrasound.Results: In obese children, there were blood lipids metabolic disorders. The levels of cholesterol, triglyceride, low-densitylipoprotein and apolipoprotein B were higher, while high-density lipoprotein and apolipoprotein A level lower in obese children. Systolicblood pressure and diastolic blood pressure in obese children were higher than those in controls. The left ventricular end-diastolic diameter, septal wall thickness and posterior wall thickness were greater in obese children. The E peak and E/A ratio lower and A peak higher in obese children than heathy children.Conclusion: Cardiac output in obese children increases in proportion to body weight to meet the higher metabolic demands that accompany excessive accumulation of adipose tissue. Due to the increase of circulatory blood volume and the rise of blood pressure, their preload and afterload of the heart increased. The overload work has impaired heart function. With blood lipids metabolic disorders, higher blood pressure and impaired heart function, obese children are more liable to suffering from cardiovascular system disease, such as coronary heart disease. The childhood obesity has already become a severe health and social problem. The prevention and control of childhood obesity is necessary and urgent and it is alsohelpful to inhance children health and reduce the incidence and mortality of cardiovascular system disease in adulthood. |
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