Expression Of Testicular INOS In Varicoce Rats And Influence Of Sheng Jing-Solublegranule To INOS Expression

Objective: To prove iNOS expression in varicocele rats testis.To discuss influence of Sengjing-soluable-granules to testicular iNOS expression in varicocele rats.Then discuss and reveal molecular level. M ethods:Experimental varicocele was created in male rats by partial ligation of left renal vein .The study were divided into 3 groups randomly:varicocele group(VG),shan operation group(SOG), treatment group(varicocele+chinese traditional medicine group VMG).The histology was observed at the 3rd postoperaative month.Results:Et was found that(l) the left testicular weight in VG was far lower than that in SOG(p<0.001).(2) the pathologic changes in VG were severer than that in VMG.(3)Amount of iNOS positive leydig cell decreased in varicocele testicular tissue on the whole .most of leydig cell showed iNOS intensely negative in VMG rats testis. Conclusions: According to the experiment confirmed that soluble granules of Shengjing protected can protect the testicular tissues of varicocele rats and alleviate testicular pathologic damage ; The amount of iNOS expression decreased in varicocele rats testis.