Clinical And Experimental Study On Chronic Aplastic Anemia And Influence On Apoptosis Of Relative Hemopoietic Stem Cell's Gene And Cell Factor By The Soluble Granules Of Bu Sui Sheng Xue

In this article, the treatment group including 36 cases of chronic aplastic anemia(CAA) patients were treated by the soluble granules of Bu Sui Sheng Xue (BSSX) which comes from professer Suen wei zheng's clinical experience more than 30 years.Qbserved ? the changes of hemogram mylogram and curative effect,compared with 20 cases of the control group .The result showed that the difference after treatment was significant (P<0.05) between two groups.It prompts that the soluble granules of BSSX's currative effect for CAA is better than the tablet of Zai Zhang Sheng Xue.In the experiment studty,detecting bone marrow was applied double- label immunohistochemical and ELISA method before and after treatment in two groups,and compared with the normal group.The result showed that the soluble granules of BSSX could raised CD34~N CD34~bcl-2 expression level ,decrease CD34c-myc-. IFN- Y TNF-. a expression level. It indicated that the soluble granules of BSSX is effective for CAA by repressing apoptosis of hemopoietic stem cell,varying relative gene of apoptosis of hemopoietic stem cell and increasing the quantity of hemopoietic stem cell.In the studty, we observed that Kindey Yang Deficiency was better to patient's condition and easier to treat than Kindey Yin Deficiency.The CD34~+. CD34~bc1-2 expression level of Kindey Yang Deficiency type was higher than that of Kindey Yin Deficiency type, CD34~c-myc IFN- +. TNF- a expression level was lower than Kindey Yin Deficiency type before and after treament.It may be the main mechanism of he treatment to Yin Deficiency is more difficult than Yang Deficiency...