| Objective: To explore systematically the pathologic mechanism of treating trigeminal neuralgia from theoretical, clinical and experimental aspects on the grounds of summing up the documentation and clinical experience. Methods: 30 patients are divided into two groups at random: cases in treatment group are treated with Shufengning granula; cases in control group are treated with Carbamazepine. In experimental study, the effect of Shufengning granule in reducing the degree of pain and calming the model animals, and the plasma level of neuropeptides are observed. Results: The clinical observations show that the notably effective rate of the treatment group is 46.67 % , and the total effective rate is 86.64%; while the notably effective rate of the control group is 20.00%, and the total effective rate is 80.00%.The difference between the two groups is significant(P<0.05). And there is a significant difference at the aspect of improving the minor symptoms between the two group (P<0.01). The results in animal experiments show that Shufengning granule has the same effect as Carbamazepine, and can significantly increase the plasma levels of β -endorphin( β -EP) and decrease the levels of substanceP(SP) and calcitonin-gene-relatedpeptide(CGRP).Conclusions: Based on deeply exploring the mechanism and therapeutic method of trigeminal neuralgia, a new effective recipe is found, and further study could be carried out. |
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