Prevalence Of Aspirin Resistance In Patients With Cerebral Infarction

Objective To evaluate the prevalence of aspirin resistance in patients with cerebral infarction and to analyse the clinical predictors of aspirin resistance. Methods Patients with cerebral infarction received 100mg/d of aspirin for 10 days. Aspirin resistance was analysed by examination of blood platelet aggregation induced by adenosine diphosphate(AD) and arachidonic acid(AA). Results There were 8.24% of the patients being aspirin resistant and 30.59% of being aspirin semiresponders. Patients who were either aspirin resistant or aspirin semiresponders were most likrly to be the elderly and women and more likely to be smokers(11.53% vs 5.05% P<0.01) as compared with aspirin sensitive(AS) patients. Conclusion The detection of aspirin resistance is particularly important for the large number of patients relying on this medication for antiplatelet therapy and prevention of cerebrovascular events. The safe alternative antiplatelet agent for long administration should be used if aspirin resistance appears to be an emerging direction of antiplatelet therapy.