The Study On The Expression And Significance Of Survivin,PTEN And C-jun In Tissues Of Human Pancreatic Carcinoma

Objective To study the expression of Surviviru PTEN and c-jun on genesis and development of pancreatic carcinoma.Method The expression of Survivin , PTEN and c-jun was detected by the S-P immunohistochemistry method in 50 cases of pancreatic carcinoma and 10 cases of non-tumor pancreatic tissues.Result Survivin was expressed in 33 of 50 pancreatic carcinoma (66%), In contract, no expression of Survivin in non-tumor pancreatic tissues was detectable (P < 0.01).The expression rate of PTEN was 40%(20/50),PTEN was found in 7 of 10 non-tumor pancreatic tissues. C-jun was expressed in 26 of 50 pancreatic carcinoma (52%), In contract, no expression of c-jun in non-tumor pancreatic tissues was detectable (P < 0.01). There were statistically significant correlation between Survivin and PTEN. The analysis of single factor revealed that the expression of Survivin and PTEN was significantly related with the prognosis of patients.Conclusion A high expression of Survivin PTEN and c-jun in pancreatic carcinoma suggests that they may play an important role in the developmentof pancreatic carcinoma. Detection of these proteins has positive effects on early diagnose, malignancy determination, prognosis and treatment of pancreatic carcinoma.