The Relation Between The Serum C-reaction Protein And Tumor Necrosis Factor-alpha And Microalbuminuria In Type2 Diabetes

Objective To explore the changing concentrations of serum CRP, TNF-a and its relation to microalbuminuria in type 2 diabetes. Subjective and Methods 60 cases of type 2 diabetes mellitus patients diagnosed according to the criteria on diaketes mellitus of WHO in 1998,were on average divided into normal albuminuria group including 16 males and 14 females and microalbuminuria group including 18 males and 14 females, according to urine albumin excretion rate (UAER) . 20 cases of heath subjects with matched gender,age and body mass index were regarded as normal control gtoup.24 houre of urine volume.urine microalbuminuria,serum concentrations of CRP and TNF-a were measured,detevmined and compared among the above three groups, urine microalbuminuria was detemined twice in each wrine sample and averaged so that UAER was calcwated.for accuracy urine microalbuminuria and serum level of TNF-a were detected by radiommunoassay and serum CRP was dertermined with immunoturbidimetric assay. Results The concentrations of serum CRP and TNF-a in thpe 2 diabetes were significantly higher than those of healthy peaple (p<0.01) . CRP and TNF-a in the microalbuminuria group was significanthy hgher than those in normal albumnuria group (p<0.05 ) .Conclusion Serum contents of CRP and TNF-a are related to T2DM and its microalbuminuria.Chronic inflammation may mediate the occurrence and development of T2DM and its microalbuminuria.