Microvessel Density And Expression Of CD105,CD31 In Gastric Carcinoma And Their Significance

Objective: To investigate the microvessel density (MVD) and the expression of CD 105 and CD31 in the tissue of gastric carcinoma and their relationship with tumor invasion and metastasis, and to evaluate the relationship of MVD value with the prognosis of patients of gastric carcinoma. Methods: After operation, section preparation of 61 patients of gastric carcinoma without radiotherapy, chemotherapy or immunotherapy before operation was examined by using S-P immunohistochemical method to detect the expression of CD 105 and CD31, and the microvessel in the tumor tissue was counted quantitatively. Results: Under the field of vision of 200 times, the value of MVD marked with CD 105 and CD31 in the gastric carcinoma had significant difference in both the depth of carcinoma invasion and metastasis of lymphatic nodes(P<0.05). Kaplan-Meier analysis showed that patients with CD105<14 and CD3K34(X200) had better prognosis and that patients with CD105 ≥14 and CD31 ≥34(X200) did not. Conclusion: The value of MVD in the gastric carcinoma is correlated with the biological behavior of the carcinoma, which suggests that the analysis of the genesis of tumor vessel and the count of MVD are an important index in evaluating the prognosis of patients of gastric carcinoma.