Relationship Between SICAM-1 And CT Scan Value In Newborns Infants With Hypoxic-ischemic Encephalopathy

Objects: To investigate the change of serum sICAM-1 and brain CT value in patients with HIE, as well as the variations of them.It can be used to provide the objective evidence in early diagnosis, evaluation the degree of brain damage and study the pathogenesis of HIE. Methods: We detect the level of serum sICAM-1 by ELISA in 30 HIE and 10 control full-term infants, CT values were obtained with huanxing Simens type of CT.meanwhile, collecting the clinical information. Results: The serum sICAM-1 levels in HIE group were significantly higher than those of contuol group. at different stage of HIE,severe group were much higher the moderate and light group. There were no significant difference between light group and control group. The brain CT values of HIE group were lower than control group,severe group were much higher the moderate and light group.With correlation analysis, negative correlations were founded between serum sICAM-1 and brain CT values.Conclusions: The measurement of serum sICAM-1 and brain CT values has a important value to decide the degree of HIE, to evaluate the level of the brain damage and estimate the prognosis.