Study On Relationship Between Plasma Lipid Level,Mild Cognitive Impairment And TCM Phlegm-Stagnation Syndrome

Objective: 1. To explore the association between dyslipidemia and MCI through case-control study, provide reference for further prevalence study. 2. To explore the distribution of basic TCM syndromes in MCI, especially the distribution of phlegm—stagnation syndrome in MCI, provide reference for further TCM syndrome study in MCI. 3. To explore the association between hyperliper and phlegm—stagnation syndrome in MCI; And explore the association between hyperliper and phlegm—stagnation syndrome of TCM.Methods: We establish MCI Clinical questionnaire to investigate the inpatients and retired-employee, 42 MCI patients and 45 normal individuals aged 50 to 80 years were involved. These objects' TCM symptom, clinical character were investigate. Plasma lipid level of 32 MCI patients and 40 normal individuals were also collected, including total cholesterol (TC), triglyceridemia (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL),apolipoprotein A1 (ApoA1),apolipoprotein B (ApoB). Finally the database was established, 1:1 case-control study was used to explore the association between plasma lipid level and MCI. The distribution of TCM syndromes in MCI, the association between plasma lipid level and phlegm—stagnation syndrome, the character of neuropsychological testing in MCI, and the clinical character of MCI were also explore through statistical analysis.Results: (1) In 1:1 case-control study, The plasma ApoAl level of MCI group is lower than that of control group (P<0. 05), the difference of other plasma lipid level between MCI group and control group is not significative. (2) In TCM syndrome study, The most common syndrome of MC1 is deficiency complicated with excess, occupied 80.9%. Kidney deficiency is the most common syndrome in six basic TCM syndrome, occupied 81%. The other ones are blood stagnation syndrome (52. 4%),heart-blood deficiency (52.4%) ,spleen-qi deficiency (45.2%) and phlegm syndrome (38. 1%), the phlegm —stagnation syndrome occupies 73.8%. (3) There was not significative correlation between plasma lipid level and phlegm-stagnation syndrome. (4) In the study on neuropsychological testing, GDS and CDR shows high coherence. The sensitivity and specificity of MMSE testing for MCI diagnosis is 61.9% and 74.3%. Mono factor analysis indicate the scores of sub item of MMSE including place orientation, accountability, language expression, language repetition is significant for MCI diagnosis. (5) In the study on clinical characteristics of MC1, the common clinical...