Association Between Intercellular Adhesion Molecule-1 Gene K469E Polymorphism And Ischemic Cerebrovascular Diseases

Objective: intercellular adhesion molecule-1(ICAM-1) has been implicated in the pathogenesis of ischemic cerebrovascular diseases (ICVD) and atherosclerosis(As). Recently, an association between the K469E polymorphism of ICAM-1 and ischemic cerebrovascular disease has been reported in several studies. To investigate the association between ICAM-1 gene K469E polymorphism and ICVD in Chinese population,we conducted a case-control study.Methods: 112 ICVD patients (36 cases of TIA and 76 cases of cerebral infarction) and 105 control subjects were recruited and the K469E polymorphism of ICAM-1 gene was analyzed by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP).The measurement data was analyzed statisticly by t-test and enumeration data by chi-squere test.Results: The average age of ICVD group and control group (64.92±11.16 and 63.91±11.96 respectively) is of no difference (P = 0.523).The percentage of male between two groups has no significant difference (x2 = 0.52, P=0.472).The history of hypertension, diabetes, hyperlipodemia and smoking in ICVD group are all higher than control group(P<0.05).The KK genotype frequencies in the ICVD group and control group were 0.527 and 0.4, respectively. The prevalence of the K allele was significantly higher in the ICVD patients (x~2 = 6.849, P =0.009,OR 1.71,95% CI 1.14—2.57). Analysis by ICVD subtypes showed that the KK genotype frequency was of no difference between TIA and controls but was significantly different between cerebral infarction and controls.Conclusions: The intercellular adhesion molecule- 1(ICAM-1)gene K469E polymorphism is implicated in the pathogenesis of ICVD and may be a risk factor for ICVD independent of hypertension, diabetes, hyperlipodemia and smoking .