| Objective To study the autarcetic function of the erythrocyte and the expression change of CR1 (i.e., CD35) on erythrocytes through comparison between normal control group and chronic urticaria patients, and explore the possible mechanism in the pathogenesis of chronic urticaria.Methods Normal control and chronic urticaria groups were comprised of people specially selected according to the mentioned standards. Rose rate of red cells adhering to cancer cells were counted after adding reagents to flesh vein bloods. At the same time, Expressions of CRl on erythrocytes were analyzed through Flow Cytometer after sample labeling. Test for correlation between rose rate of red cell adhering to cancer and the expression of CRl on erythrocytes was carried out.Results Compared with the normal control, rose rate of chronic urticaria patients' red cells adhering to cancer cell and the expression of CRl on erythrocytes were higher (p<0.05). The rose rate of red cells adhering to cancer cell and the expression of CRl on erythrocytes showed positive correlation (p<0.01) for the normal control, while there was not correlation between them for the chronic urticaria patients (p>0.05).Conclusions (1)The rose rate of red cells adhering to cancer cell and the expression of CR1 on erythrocytes of chronic urticaria were higher than that of normal control, increases in the expression of CRl on erythrocytes and their activity may be the basis of hyperfunction and disorder of the autarcetic function of erythrocytes in chronic urticaria. (2)The adjust and control unbalance of erythrocyte autarcetic function to the cell mediated immunity and humoral immunity may result in the chronic urticaria.
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