The Use Of Remifentanil-propofol Infusion In Children Total Intravenous Anesthesia

Objective: To discuss the efficacy, safty and controllability of total venous anesthesia using remifentanil and propofol in short pediatric operations. Methods: 80 undergoing lower abdomen surgery patients were enrolled in a double-blinded, randomized trial and we randomly allocated them to one of four groups: in induction period remifentanil 3μg ·kg-1, Propofol 2mg·kg-1 were infused in 2 minutes, and propofol infusion at 8mg· kg-1· hr-1 in maintaining period, (1) remifentanil infusion at 0.15 μg· kg-1· min-1 (GroupO); (2) remifentanil infusion at 0.20 μg · kg-1 · min-1 , (3) remifentanil infusion at 0.25 μg· kg-1· min-1. Monitoring BP, HR, ECG, SpO2, AAI, blood sugar. Results :(1) There is a significant decrease in mean arterial pressure of Ⅰ Ⅱ Ⅲ groups,and nonsignificant increase after incision. And in O group it is opposite.(2)There is no significant change of the heart rate. (3) There is no significant change of the blood sugar. (4) After the induction,the AAI data decreased in all the groups.And only the data in O group increased significantly after incision. Conclusions: Comparing with inhaled anesthesia, infusion-based anesthesia using remifentanil and propofol is associated with better hemodynamic stability, and better recovery profile. And induction with remifentanil 3μg kg-1, propofol 2mg·kg-1 in 2 min, and maintaining with remifentanil 0.20μg· kg-1 · min-1 , propofol 8mg· kg-1· hr-1, is the best project.