| Objective: To study the features of coronary angiography and relationship between carotid atherosclerosis (CAS) and coronary artery atherosclerosis (CAAS) and risk factors in patients with coronary heart disease with type 2 diabetes .Methods: 88 hospital patients with positive coronary arteriography were divided into two groups: diabetes mellitus (DM)group (n=42) and nondiabetes mellitus(non-DM) group(n=46). The two groups includeed three subgroups according to the number of coronary artery involved: 1-branch, 2- branch, 3 -branch. All the patients underwent recoding of smoking, systolic blood Pressure (SBP), diastolic blood pressure (DBP) , duration of diabetes, body mass index (BMI), and examination of fasting blood glucose(FBG),total cholesterol(TC),triglyceride (TG) low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol(HDL-C),serum uric acid (SUA). The intima-media thickness(IMT), and plaque of carotid arteries were measured by ultrasonography .The relationship between CAS and CAAS was analyzed by straight line correlation analysis. The risk factors for coronary heart diseases in patients with diabetes were analyzed by multiple stepwise regression analysis.Results: There was no statistical difference in age, TC, LDL-C level, smoking index between two groups (p>0.05).Compared with non-DM group, SBP, DBP, TG, BMI, SUA were higher in DM group, while HDL-C level was lower (p<0.05). The 1 -branch lesion proportion was lower in DM group than in non-DM group (p<0.05), while the 3- branch lesion and diffusive lesion and occlusive lesion reversed. The number of coronary arteries involved and diffusive lesion and occlusive lesion in DM group were significantly higher than those in the non-DM group. The number of left main coronary artery lesions, and coronary collateral circulation were a little higher in DM group than in non-DM group, but it did not reach statistical significance(p>0.05). The coronary artery lesion proportion had relation with the duration of diabetes of DM group. 3- branch lesion proportion was higher over 5 years .The longer the duration of diabetes, the more branch were involved. IMT and Crouse score and detectable rate of plaque in DM group were higher than those in the non-DM group. The more coronary artery lesion, the thicker IMT and higher Crouse score. A liner correlation between Gensini score and IMT and Crouse score was found (r=0.46, 0.43 p<0.01). The same relation was also found in the number of coronary branch lesion and IMT and Crouse score(r=0.68, 0.62 pO.OOl). A significant positive correlation of Gensini score to age, duration of diabetes, smoking index, SBP, DBP, TG, SUA was found in the DM group, and the same relation was also found in the number of coronary branch lesion to age, duration of diabetes, SBP, DBP, TG, SUA. The negative correlation of Gensini score and number of coronary branch lesion to HDL-C. Multiple stepwise regression analysis indicated that age, HDL-C SBP, DBP, TG, SUA, duration of diabetes, were correlated to the extent of coronary artery lesion in DM group.Conclusion: The patients in DM group had sever and diffusive lesion and much great extent of coronary artery involvement. There was close relationship between extent of CAS and CAAS in the DM group. Ultrasonography may predict the extent of coronary artery lesions. The risk factors of extent of coronary artery lesions were lowHDL-C level, SBP, DBP, high TG level , SUA, duration of diabetes, advanced age in this kind of patients. |
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