The Study Of Risk Factors Of Atherosclerosis Disease In Type 2 Diabetes

Objective: To explore the risk factors of atherosclerosis disease in the patients with type 2 diabetes mellitus. Methods: Serum free fatty acid (FFA), total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), fasting blood glucose(FBG), glycosylated hemoglobin(HbAic), high sensitive C reactive protein(hs-CRP), tumor necrosis factor-a(TNF-a), fibrinogen(FIB) were tested in 170 type 2 diabetics and 74 non-diabetics as control group. These exposing factors and the incidence of atherosclerosis disease were compared in diabetic group and non-diabetic group by case control study. These exposing factors were compared in the groups with atherosclerosis disease and without atherosclerosis disease in diabetics and the risk factors of atherosclerosis disease were analyzed in statistic method. Results: The incidence of atherosclerosis disease in type 2 diabetics was higher than control group (x~2=15.526, P=0.000, OR=3.088) and the confidence interval of 95% OR was 1.757—5.427. Multivariant Logistic regression analysis showed that the most important risk factor for atherosclerosis disease in type 2 diabetics was low density lipoprotein cholesterol (LDL-C). The incidence of atherosclerosis disease in diabetics whose LDL-C was higher than 2.6mmol/L was 3 times that of whose LDL-C was lower than 2.6mmol/L (x~2=11.987, P=0.001, OR= 3.073), and the confidence interval of 95%OR was 1.612—5.860. Conclusion: The incidence of atherosclerosis disease in type 2 diabeticswere3 times that in non-diabetics. Low density Hpoprotein cholesterol (LDL-C) was the most important risk factor of atherosclerosis in type 2 diabetics.