| Objective To investigate Expression of E-cadherin, a-catenin and β-catenin in human cervical cancer and its relationship with the biological bahavior.Methods Immunohistochemical S-P method was used in 41 cervical cancer and 10 normal cervical sampes for detection the expression of E-cadherin, a-catenin and β-catenin.Results (1) E-cadherin, a-catenin and p-catenin proteins showed normal expression In 10 normal cervical tissues, The abnormal expression rates of E-cadherin, a-catenin and β-catenin in the tissues of cervical cancer were 51.2%, 68.3% , 41.5 %, respectively. The total abnormal expression rate of E-cd/cat complex in 41 cases of cervical cancer was 80.5%. (2) Abnormal expression of E-cadherin was significantly correlated with tumor proliferation status (P<0.05). (3) Abnormal expression of E-cadherin and a-catenin were significantly correlated with tumor differentiation status (P<0.05, P<0.01). (4) The rates of abnormal E-cadherin, a-catenin and p-catenin were higher in tumors with lymph node metastasis positive than that in tumors without lymph node metastasis (P<0.01, P<0.05, P<0.01). (5) The frequence of abnormal a-catenin was correlated with the depth of cancer invasion in cervical cancer (P<0.05). (6) The consistency and degree of expression of E-cadherin and a-catenin significantly correlated with each other (r =0.384, P<0.001).Conclusions 1. Abnormal expression of E-cadherin and its associated protein catenins occur frequently in human cervical cancer. 2. The abnormal expression of E-cadherin, a-catenin and β-catenin is closely correlated with the biological bahavior of cervical cancer, the coexpression of E-cd/cat can be more exact and sensitive at predicting invasion and metastasis in cervical cancer. 3. The detection of E-cadherin, α-catenin and β-catenin proteins may be useful markers for assessing biological characteristics of human cervical cancer. |
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