Analysis Of The Peripheral Blood Lymphocyte And The Subsets For The Patients With Sialaden Tumor

Objective: To observe the lymphocytes and the subsets in the peripheral blood of the patients with sialaden benign or malignant tumors, and evaluate the cellular immune function of patients by flow cytometry, also to investigate the relationship between the occurrence, development, curative effect, prognosis of the tumor and the immune state of the body. Methods: The samples of peripheral blood from patients with sialaden malignant tumor (13 cases, group 1, exp 1), benign tumor (16 cases, group 2, exp 2) and 10 healthy persons (control group), were examined by flow cytometry (FCM) to detect the number of the T-lymphocytes and the subsets, B-lymphocytes, and natural killer cells (NK). Result: In peripheral blood, (1) The count of all lymphocytes (CD3~+) was decreased in Exp 2 comparing to control group and Exp 1(p<0.05). (2) The count of CD4~+ lymphocytes was decreased too in Exp 2 comparing to control group and Exp 1(p<0.05). The count of CD8~+ lymphocytes was increased in Exp 2 and the ratio of CD4~+/CD8~+ was decreased comparing to control group and Exp 1 (p<0.05). (3) The count of CD19~+ was lower than Exp 1 and control groups (p<0.05). (4) The count of NK was decreased significantly comparing to control group and Exp 1(p<0.05). Conclusion: This study demonstrated that the immune function of the body was abnormal in patients with sialaden malignant tumor, especially the cellular immunity. If the immune function was better, the prognosis would be better as well. It is suggested to detect lymphocytes and subsets in peripheral vein blood in patients with malignant sialaden tumor for...