The Expression And Biological Significance Of Heparanase, VEGF, NF-κB CD34 In Gastric Carcinoma

Objective:Gastric carcinoma is one of malignant digestive tumors in our country. Patients with gastric carcinoma died from metastasis of gastric carcinoma. It has been known that combined biological effects of multiple genes are involved in the carcinogenesis of gastric tissues and metastasis of gastric carcinoma. The purpose of this study was to investigate the expression of Heparanase, VEGF, NF-κB, intratumor microvess -el density(MVD) and DNA content in gastric carcinoma to explore their role in carcinogenesis and metastasis of gastric carcinoma and to try to provide referential indexes to the treatment of gastric carcinoma.Methods:1 The expression of Heparanase, VEGF, NF-κB and MVD were examined by s-p immunohistochemical stain(IHC) in 86 gastric carcinoma and 23 adjacent carcinoma and 14 normal gastric mucosa.2 The expression of Heparanase and DNA content in 50 gastric carcinoma and 25 adjacent carcinoma and 10 normal gastric mucosa were quantitatively examined by flow cytometrye (FCM).