| Objective: This article discussed the clinical effective of Busuishengxue granule to Myelodysplastic Syndrome (MDS) patients, and observed the difference in expression level of myelo-cytokine c-met in MDS patients before and after treatment.Method: 60 MDS patients taken into account were divided into experiment group and control group at random by SAS software in which 30 patients in the former group while 30 in the latter one. Three months was described as one period of treatment. After two periods, clinical effect was observed, the change of hemogram, myelogram and the expression level of myelo-cytokine c-met were analyzed.RESULT: 1.After treatment, there is significant improvement of anemia and hemorrhage symptom and peripheral blood and significant discrease of immature cells in peripheral blood in treatment group, and compared with that before treatment, the differences is significant (P<0.05) and the improvement degree is superior to that in the controlled group(P<0.05).2.The expression level of bone marrow hematopoietic cell c-met in MDS patients was higher than that of the control group. After treatment the expression level in two groups were descended to different extend. The descendment in experimental group was superior to that in contral group.Conclusion: 1.There was abnormal expression of bone marrow c-met in MDS patients. 2. Busuishengxue granule can adjust the expression of expression level of marrow mononuclear cell to improve hematopoiesis in bone marrow. 3. Busuishengxue granule is an effective drug to treat MDS, and is worthy of further study and development. |
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