Study On The Distribution Of Sappan Wood Ethyl Acetate Extract In Orthotope's Heart And Other Organs Of The Cardiac Allograft Rats

Purpose: In this study,through researching the distrbution of the sppan acetic ether extrect in the heart and liver , kidney, spleen, thymus gland of the cardial allograft SD rat.Method: In this study, Adult heart clear inbred strain closed colony SD rat is the receiver, wistar rat is the provider, the sum is 15 respectively.build up an model of cardial allograft in big rat belly . Establish the sppan body outside chemistry composition set, the model matched control and sppan acetic ether extrect set respectively, to collect the heart and liver, kidney, spleen, thymus gland of the recepters and providers after 11 days of opration. ues the metherd of anti- mutually HPLC to examinate the distribution of sppan acetic ether extrect in the heart and liver , kidney, spleen, thymus gland of resepters and providers qualitatively , and ues microscope to examinate the the body heart pathology changes of providers .Result:we discover the sppan acetic ether extrect and metabolism outcome in heart and liver, kidney,spleen,thymus gland of providers and recepters , sppan acetic ether extract may alleviate the impairing of acute rejection to the myocardial.Conclusion: the sppan acetic ether extrect and metabolism outcome in heart and liver ,kidney,spleen,thymus gland of providers and recepters of cardial allograft rats, sppan acetic ether extract may alleviate the impairing of acute rejection with the protection function to the transplanted heart .