Study On The Genetic Polymorphisms Of Homocysteine Metabolic Related Enzymes In Patients With Coronary Heart Disease

BackgroundCoronary heart disease (CHD) is a common disease that threatens that people's health seriously, the pathogenesis of which is not yet understood sufficiently.Some studies have found that many CHD patients haven't these traditional coronary risk factors like diabetes mellitus,hypertension,hyperlipidemia and smoking history. But there are elevate levels of homocysteine in many patients. So studies have paid more attention to the functions of Hcy on the pathogenesis of CHD. Hyperhomocysteinemia has been implicated as an independent risk factor for CHD. Hcy is a key branch-point intermediate during the ubiquitous methionine metabolism. Lack of related enzymes or co-factors in the homocysteine metabolism can induce hyperhomocysteinemia and cardiovascular disease. The gene mutations of Methylenetetrahydrofolate reductase (MTHFR) ,cystathionine 6- synthetase (CBS) and methionine synthetase (MS) ,which are the key enzymes can result in loss or decrease of enzyme activity .There are different results in the studies .There exists ethic,geographic or sample size diference.