Effects On Monoamine Neurotransmitters In The Cerebral Cortexes Of Senile Model Rats Treated With Medicine-separated Moxibustion On Shenque Acupoint

Objective: Observe the effects on monoamine neurotransmitters, SOD, MDA, MAO in the cerebral cortexes and the memory of senile model rats treated with medicine-separated moxibustion on Shenque acupoint, and discuss the functional mechanism of postponing senility. Method: Choose 42 senile model rats (3 months old, 160-180g weight, 21 male and 21 female). Separate them randomly into four groups. Group A is control group, Group B is senile model group, Group C is senile group with medicine-separated moxibustion on Shenque acupoint, Group D is control group with Western senility medicine. Results: Treatment with medicine-separated moxibustion on Shenque acupoint can change both the concentrations of NE, DA, 5-HT, MDA and the activity of SOD, MAO in the cerebral cortexes. Concentrations of monoamine neurotransmitters were increased while those of MDA were decreased; Activity of SOD was increased while that of MAO was decreased. And it can improve the memory of senile rats. Conclusion: Treated with medicine-separated moxibustion on Shenque acupoint, the aging process of the monoamine neurotransmitters in the cerebral cortexes of senile model rats can be slowed, the ability of eliminating free radicals can be enhanced, and the memories of the rats can be improved. This provides evidence for the clinical use of medicine-separated moxibustion on Shenque acupoint.