The Correlative Research Between Nitric Oxide Pathway And Essential Hypertension

Objective: The study was designed to investigate the relationship between nitric oxide pathway and Intima-Media Thickness(IMT) in essential hypertension (EH) in order to provide a new method for the diagnosis and treatment of EH.Methods: Fifty-three patients with EH and twenty-two normal individuals were selected to measure their blood pressure,weight and other routine test, IMT with Ultrasound,as well as the serum NO, NOS and SOD in different ways. In fifty-three patients with EH, blood pressure and serum lever of NO were measured after treatment for 3-months.Results:①Serum NO, NOS and SOD levels in patients with EH(53.92±16.30μmol/L,20.69±3.51U/ml,91.15±16.18U/ml)were significantly lower than that in normal controls(68.66±17.16μmol/L,32.73±4.44 U/ml,103.89±14.28 U/ml, P < 0.05).②There were significant differences in the levels of serum NO,NOS and SOD among the 2 clinical grading of EH(the first grade follows as 58.33±16.39μmol/L,22.10±3.09 U/ml,95.10±15.53 U/ml ,the second grade follows as 48.18±14.59μmol/L,18.85±3.19 U/ml,85.99±15.87 U/ml, P < 0.05).③Levels of serum NO were lower in EH with IMT≥0.09cm (46.57±12.72μmol/L)than EH with IMT<0.09(67.07±13.67μmol/L), and levels of serum NO correlated negatively with IMT.④After 3-month's treatment,the increase of serum NO were more significant in patients with normal blood pressure than patients with abnormal blood pressure (75.13±13.32μmol/L and 63.26±14.92μmol/L,P < 0.05).Conclusions: NO is probably involved in the pathophysiological process of EH and Carotid Artery restructuring.