Research On Pharmacological Methodology For Screening Anti-fatigue Drugs From Chinese Materia Medica

Nowadays, fatigue is a serious matter along with the rush of modern life and operating pressure. So it is exigent to research anti-fatigue drugs.By making use of the dominant position in pharmacy, electronic, engineering and computer sciences, and by converting the behavior into locus patterns of photography and computer - based auto - controlling , a computer - based auto - controlling and imaging - analyzing processing system was first developed in this country for swimming tests in animal. It can offer a set of evaluation system for anti-fatigue drugs.By videotape, the locus of mice movements can be noted on real time. For checking up the reliability of the system, many experiments are done. The results sugget that data acquired between the computer group and the manual group in mice are consistant.However, in addition to death time (DT), this system can provide more information including swimming distance (SWD), average speed(AS), swimming time (SWT), swimming time rate (SWR), immobility time (IT) , immobility time rate (ITR), swimming speed 1(SS1), swimming speed 2(SS2), swimming speed 3(SS3), first sinking time (STO), sinking time (ST), sinking time rate (STR), number of sinking (NS) and locus(L), which have proved to be more systematic , scientific and reasonable for the judgment of the effect on anti-fatigue drugs.