Comparative Study Between Clinical And Pathology Diagnose With Chronic Hepatitis B Virus

Objective:The aim of this study was to assess the clinical relative factors , pathology diagnostic and their correlation between HBeAg postive and HBeAg negative chronic hepatitis B (CHB). And to determine the difference of the pathology diagnosis between liver biopsies with chronic hepatitis B. And to investigate the alpha-smooth muscle actin, hepatic fibrosis in chronic hepatitis B.Methods:For assessing the histopathological features and its relation to alanine aminotransferase,bilirubin,albumin,HBV DNA levels in HBeAg positive and HBeAg negative chronic hepatitis B, liver biopsy samples of 260 chronic hepatitis B were scored according to histological hepatitis activity index (HAI).Comparation of the diagnostic difference of two spots of liver biopsy in 55 patients with chronic hepatitis B has been done. Human liver biopsies were divided into four groups according to the degree of liver fibrosis, samples were stained with anti-alpha-smooth muscle actin antibody by immunoperoxidase method.Results:There was no association between HBVDNA levels and liver histological damage in HBeAg-positive patients.Alanine aminotransferase...