| Objective Cytokines play a part role in the pathogenesis of asthma and recent studies found there are some associations between the pathogenesis of asthma and polymorphisms of several cytokines. Interleukin-10 is an antiinflammatory cytokine in asthma that plays a role in both immunoinhibition and antiinflammation. But the association between the polymorphism of IL-10 gene and hereditary susceptibility in children with asthma is unknown. In order to explore the hereditary susceptibility of children with asthma, we detect the association between the single nucleotide polymorphism (SNP) of IL-10 and childhood asthma to investigate susceptibility in children with asthma. Methods Subjects of Han ethnic were selected from Kunming City in China. The study was conducted in two different groups. 50 asthmatic children were... |
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