Expression And Implication Of Estrogen Receptors And Progestogen Receptors In Premalignant And Malignant Lesions Of Breast Of Women

Objective: To observe the expression and clinical implication of estrogen receptors and progestogen receptors in premalignant and malignant lesions of breast of women.Methods: Here is a retrospective research . The relevant features of 40 patients (52 breasts) who had hyperplastic disease resected in the Breast and Thyroid Surgery Department of China-Japan Union Hospital of Jilin University. In control group, tissue was obtained from an age matched series of 50 patients (52 breasts) who had malignant breast neoplasm resected. By SP of immunohistochemical method.Results: The expression of ER in pure hyperplastic lesions,light, moderate , severe hyperplastic lesions and malignant lesions were 30.00%, 41.67%, 44.44%, 61.90%and 69.23%. The expression of PR in pure hyperplastic lesions,light, moderate , severe hyperplastic lesions and malignant lesions were 20.00%, 25.00%, 44.44%, 52.38%和55.77%. The expression of ER positive and / or PR positive in pure hyperplastic lesions,light, moderate , severe hyperplastic lesions and malignant lesions were 30.00%,41.67%,55.56%,66.67%and 69.23%Conclusion: 1. The expression of ER, PR between pure hyperplastic lesions and breast neoplasm is remarkable. The pertinency between light, moderate , severe hyperplastic lesions and breast neoplasm is gradually increased . 2.We can judge the potential risk of a hyperplastic lesion by its ezpression of ER, PR. 3. The retrospective research can provide a gist to do the endocrine therapy on some hyperplastic mammary diseases. 4. It can't completely fit together if we compare the positive rate of ER,PR to other articals , but the total trend is that: the higher of the pathologic grade of atypical hyperplastic diseases , the higher of the pertinency between it and breast neoplasm.