Expression And Correlation Of Pokemon And NF-κ Bp65 In Breast Carcinomas

Objective: To study the expression and significance of pokemon and nuclear factor-kappaB p65 and their relationship with clinical-pathologic parameters in breast carcinomas, and to explore the correlation between pokemon and nuclear factor-kappaB p65．Methods: The expressons of pokemon and NF-κBp65 were studied in 52 cases of breast carcinomas, 20 cases of adjacent noncancerous breast tissues and 10 cases of normal breast tissues by immumohistochemical technology(S-P). Results were compared with clinical-pathologic parameters, and the correlation between pokemon and NF-k Bp65 was analyzed .Results: 1．The immunostaining of pokemon localized mainly in nucleus. The positive expression rate of pokemon was significantly higher in breast carcinoma tissues than that in adjacent noncancerous breast tissues or normal breast tissues (p<0．05) . and the rates were 71．2%(37/52) , 35%(7/20) and 20．0%(2/10) , respectively. The positive expression rate of pokemon was significantly higher in breast carcinomas with axillary lymph node metastasis than that in breast carcinoma without axillary lymph node metastasis(p<0．05) , and it did not correlate with age, tumor size, histological grading, TNM staging.et al(P>0．05) .3．NF-κBp65 showed cytoplasm and/or nucleus staining. The positive expression rates of NF-κBp65 in breast carcinoma tissues, adjacent noncancerous breast tissues and normal breast tissues were 38．5%(20/52) , 10% (2/20) and 0% (0/10) , respectively. Significant difference was observed between the positive expression rate of NF-k Bp65 in breast carcinoma tissues and that in adjacent noncancerous breast tissues and in normal breast tissues (p<0．05) . There was no significant difference between the expressions of NF-κBp65 in adjacent noncancerous breast tissues and that in normal breast tissues (P>0．05) . The expression of NF-k Bp65 in breast carcinoma has a significant correlation with histological grading, TNM staging and axillary lymph node metastasis(P<0．05) .4．There was positive correlation between the expressions of pokemon and NF-κBp65 in breast carcinoma(P<0．05) .Conclusions: 1．there is up-regulation of pokemon in breast carcinoma tissues, and up-regulation of pokemon may be implicated in the carcinogenesis and metastasis of breast carcinoma.2．There was positive correlation between the expressions of pokemon and NF-k Bp65 in breast carcinoma . It is possible that pokemon locates the upstream of NF-k Bp65 and plays an important role as a regulator of NF-k Bp65．Pokemon and NF-k Bp65 may be implicated in the carcinogenesis and development of breast carcinoma together.