Correlation Analysis Of CD34-positive Cells And LVEF,BNP In Peripheral Blood Patients With Acute Myocardial Infarction

Background Acute myocardial infarct is becoming a worldwild healthissue now. Concentration of Brain natriuretic peptide (BNP) may be usedto prognosticate the prognosis of acute myocardic infarct(AMI).A greatdeal of investigation has been approved that BNP is correlated to leftventricular remodel. Analysis of BNP and LVEF has been become an importantguidline to prognosticate AMI. Haematopoietic stem cells are unpolarizedcells which have polarized potentiality and self-copy function. At presenttime, most investigations have regarded the CD34-positive mononuclearcells as stem cells. Correlation between the mobilization of stem cellsin the peripheral blood of patients with AMI and other correlative targetis little known. So we study it.Objective To investigate the Mobilization of CD34-positive mononuclearcells and the correlation between the mobilization of CD34-positivecells and LVEF,BNP which in the peripheral blood of the patients withST-segment elevation acute myocardial infarction (STEMI).Methods 40 patients with STEMI (＜10 hours), 20 with stable angina(SA),and 20 healthy control subjects were enrolled. The number of theCD34-positive mononuclear cells was assessed by use of a flowcytometer. The STEMI subject was assessed LVEF,BNP. Data were subjectedto one-way ANOVA followed by Q test for comparison between any 2 means.Using linear regression to analyze the relationship between the numberof circulating CD34-positive mononuclear cells and LVEF,BNP.Results The number of CDS4-positive mononuclear cells in peripheralblood was significantly higher in STEMI patients than in stable anginaand healthy subjects, peaking at 24 hours after MI. Simple regressionanalysis revealed that the number of circulating CD34-positivemononuclear cells positively correlated with LVEF levels and negativelycorrelated with BNP levels.Conclusions The number of CD34-positive mononuclear cells in theperipheral blood of patients with myocardial infarction is higher thanSA and the healthy people. The mobilization of CD34-positive Cells iscorrelated to LVEF and BNP in Peripheral Blood Patients With AcuteMyocardial Infarction.