Clinical And Empirical Research Of Gubafang To Treat Acute Soft Tissue Injury

Purpose:Gubafang is a preparation summarized by professor ChenWeiliang, a famous veteran teran doctors of TCM, according to his clinicalexperience, be mainly used to treat wound earlier period of theextravasated blood hot disease, particularly be partial to extremitassuperior. The topic observe the clinical treatment effect of Gubafangto treat acute soft tissue injury, and utilize random and contrastedanimal experiment, to research the mechanism of action of Gubafang, toprovide further evidence on using and spreading.Method:(1)The literature research:We summarize and evaluate currentsituation of etiology,pathogenesis, and clinical research and empiricalstudy of TCM and modern medicine of acute soft tissue injury, by inquiringinto the survey from a great number of literatures in TCM and modernMedicine. (2)Clinical research:We observe some patients of acute softtissue injury, by dividing to Gubafang group and Yunnanbaiyaogroup, course of treatment is one week, and record the cardinal symptomand objective sign of prior treatment and posttreatment. (3)Empiricalstudy:we research the function of reparation of acute soft tissue injuryand promoting blood flow of Gubafang after forming a acute soft tissueinjury model.Result:(1)The literature research: acute soft tissue injury is themost hackneyed complication of bone fracture. There is a comparativelylarge progress in clinical management these years, not only have atraditional Chinese crude drug apozem for oral use and drug for extemaluse, also have Chinese patent medicine and drug for intervenous dropinfusion which extracted form Chinese crude drug. The experiment researchis mainly the renovation acute soft tissue injury, antiinflammatory andrelieve pain, promoting blood flow etc.. (2)Clinical research: 60 sufferers is random divided into treatment group and matched controlgroup, and then an oneself compare between prior treatment andposttreament, and a compare between two groups. The consequence showsthat all the indexes have a significance difference between priortreatment and posttreament, and Gubafang treatment group make aeffective power of 100％,and Yunnanbaiyao matched control group make aeffective power of 80.0％,chi-square criterion shows P＜0.05, havestatistical significance. It shows that both Gubafang and Yunnanbaiyaohave good therapeutic efficacy in acute soft tissue injury treatment, andis better. (3) Empirical study:①research of the function of renovationof acute soft tissue injury shows that both necrosis of muscle fiber andinfiltration of inflammatory cell in Gubafang treatment group areobviously less than Yunnanbaiyao matched control group, the model group,and close to the blank group。②the research of promoting blood flow showsthat all the indexes of heemorheology in Gubafang treatment group areobviously lower than Yunnanbaiyao matched control group and the modelgroup, and close to the blank group。Conclusion: 1. The acute soft tissue injury is the most common complicationof bone fracture, and Chinese herbal medicine occupies obvious advantagein the acute soft tissue injury. Using Gubafang to treat acute soft tissueinjury by promoting blood flow,remeveing heat to expel wind,promotingqi circulation to relieve pain, to be in line with TCM's theory, andpossess favourable research and clinical application prospect. 2. Thereis significant effect when using Gubafang to treat acute soft tissueinjury. The clinical research detected to treat acute soft tissue injuryby Gubafang, can obviously abate patient's pain and eliminate swellingof limb more quicker;empirical study discovers Gubafang can acceleratethe renovation of acute soft tissue injury, and possess a obviouslypromoting blood flow effectiveness.