Measurement Of Serum Uric Acid And High-sensitivity C-reactive Protein Level And Its Clinical Value In Patients With Coronary Heart Disease

Background: Epidemiologic studies have demonstrated that highlevels of serum uric acid(UA) were associated with coronary heartdisease(CHD), but whether the high serum UA is an independent riskfactor for CHD remained controversial. It is known to all thatinflammation is closely correlated with the development ofatherosclerosis, and the levels of high sensitivity C-reactive protein(hs-CRP) increase in patients with CHD, especially in patients with acutecoronary syndrome(ACS). However, the relationship between hs-CRPand UA in patients with CHD is still unclear.Objectives: To explore the changes of serum levels of UA andhs-CRP in patients with CHD. Furthermore, to evaluate the clinicalsignificances of these two biomarkers.Methods: We selected 211 patients with CHD admitted to ourhospital from March 2005 to October 2006, consisted of 70 patients withstable coronary heart disease(SCHD), 73 patients with unstable angina pectoris(UAP) and 68 patients with acute myocardial infarction(AMI).Otherwise, we selected 72 healthy control group. Each were examinedthe levels of UA and hs-CRP in order to find the differences andcorrelations of these markers among each group.Results:1,The concentration of UA and hs-CRP in each CHD group weresignificantly higher than in control group(P＜0.01), the concentrations ofUA in SAP group were higher than in AMI group, the concentrations ofhs-CRP in AMI group were higher than in UAP group(P＜0.01, theconcentrations of hs-CRP in UAP group were higher than in SCHDgroup(P＜0.01).2,Multivariate Logistic regression analysis revealed that the level ofUA was a significant variable associate with CHD, its B,Wald,EXP (B)and P were 0.85,6.12,2.34and 0.013.The level of hs-CRP also was asignificant variable associate with CHD, its B,Wald,EXP (B) and P were1.11,10.27,3.03 and 0.001.3,Linear correlation analysis showed the concentrations of UAwere positively correlated with hs-CRP levels in SCHD group (r=0.328, P＜0.01),The concentrations of UA were negatively correlated withhs-CRP levels in AMI group(r=-0.441, P＜0.01)Conclusions:(1)The concentrations of serum UA and hs-CRP levels in patients with CHD were significantly higher than in the healthy controls.(2)High levels of serum UA and hs-CRP are independent risk factorsfor CHD;(3)High serum levels of UA may induce inflammation reaction.(4).High levels of hs-CRP always accompany with decreased levelsof UA in patients with AMI.