| Objective: To observe the changes of HPTA and the tongue signs in mice with kidney-yang deficiency model induced by "over fatigue and sexual strain" Methods: 150 healthy male mice of Kunming species were chose,and randomly divided into five groups: contrast group, fatigue group,sexual strain group,over fatigue with sexual strain group (briefly named as model group) and group treated with JinGui Shenqi Wan. There were 30 mice in each group. Kidney-yang deficiency models were induced by forcing mice to swim to make them over fatigue and inducing male mice to sexual strain with Colldege effect. JinGui Shenqi Wan was used to treat them,then the signs were observed in the second, fourth and sixth weeks,such as the weight, temperature,TSH, T3 ,T4, tongue signs in serum and tongue histological changes. Results: The mice in model group present the typical manifestations of kidney-yang deficiency at the end of the fourth weeks. Compared with the contrast group, the weight, temperature,and TSH,T3 and T4 level in serum model group obviously decreased. The tongues of the mice in model group are whitish with obvious tooth prints. Their filiform papilla density and number cell division in tongues obviously decreased. The thickness of epidermis and the thickness of stratum cornea of the tongues obviously increased. Those in JinGui Shenqi Wan group had the tendency of increasing compared with those in model group. Conclusion: The conditions of the model mice with kidney-yang deficiency due to over fatigue and sexual strain accorded with the clinical manifestations of patients with kidney-yang deficiency,the changes of HPTA accorded with clinical researches and the influence of HPTA of other models. The pathological changed of the tongue tissues in the model mice with kidney-yang deficiency were mainly characterized by lowered increasing of epidermis,decreased metabolism. |
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