The Clinical Study Of Guchong Zhixue Decoction In Treating Emorrhapic Period Of Anovulatory Dysfunctional Bleeding With Qi Deficiency And Blood Stasis Syndrome

Objective:To explore systematically the effect and the hemostasis principle of Guchong Zhixue Decoction (GCZXD) in treating dysfunctional uterine bleeding (DUB) with Qi deficiency and blood stasis syndrome based on the theoretical and clinical research under the guidance of traditional and western medical theory . Methods: 60 patients of DUB diagnosed Anovulatory Dysfunctional Bleeding with Qi deficiency and blood stasis were divided randomly into test group(30 cases, treated with GCZXD) and control group(30 cases,treated with Yigogn Zhixue Oral Liquid). Observe the changes of the hemostasis effect,the improvements of clinical symptoms,the thickness of endometrium,the blood rheology, the uterine blood circulation, thrombin time (PT), activated partial thrombin time(APTT), the serum Ca2+ level, 6-keto-PGF1α(6-K-PGF1α) and thromboxane B2(TXB2) in the menstrual blood. Results: GCZXD could improve clinical symptoms of patients obviously and the total effective rate is 90.00% in the test group,while it is 73.33% in the control group,there is significant difference between them (P<0.05). The total sign and symptom of the test group and the control group is significantly different(P<0.01). After the treatment of GCZXD,the thickness of endometrium was significantly decreased(P<0.01). The indexes of blood rheology were significantly decreased(P<0.05). The uterine artery blood flow and the average flow speed were both increased, while the index of the resistance was decreased(P<0.05,P<0.01). The indexes of PT, APTT, 6-K-PGF1α, 6-K-PGF1α/TXB2, were significantly decreased(P<0.05,P<0.01), the indexes of serum Ca²⁺ was significantly increased(P<0.05). Conclusion: Guchong Zhixue Decoction is an effective recipe in treating DUB with Qi deficiency and Blood stasis syndrome. The effect may be achieved through the operation of improving the blood rheology, promoting cruor, adjusting the concentrations of PG, etc.