Effects Of Vecuronium On Monitoring Nerve Electrophysiology

Objective: During the process of investigating the anesthesia, to speculate the impact of non-depolarizing muscular relaxant vecuronium to electrophysiology and the feasibility of monitoring according to the fact that with the application of non-depolarizing muscular relaxant vecuronium, muscle relaxation take effect gradually in the process and gradual return of waveform monitoring changes.Method: choose 20 cases of general anesthesia in patients, ASA graded from I to II, Age from 45 to 60, among them ,there are 12 cases of male, and 8 cases of female, then monitor ECG, HR, RR, DBP, SBP, MAP, SpO₂, P_ETCO2, with a selection of peripheral nerve (the median nerve) firstly, Link the electrodes of monitoring muscle relaxation and monitoring electrodes, make the control group as monitoring the sensory active nerve potential of median nerve waveform when the patients are conscious, and they are induced by midazolam 0.05mg.kg^-1, fentanyl 2-4μg.kg^-1, vecuronium 0.1-0.15 mg.kg^-1, propofol 2mg.kg^-1. After inducement via the mouth as endotracheal intubation, anesthesia machine connected to intermittent positive pressure ventilation (IPPV), respiratory rate (RR) 12 beats .min^-1, tidal volume (VT) 8-10ml·kg^-1, respiratory ratio 1:2. during operation, P_ETCO2was maintained in a level of 35-40mmHg. After inducement of anesthesia, when starting the stimulation of train-of-four, muscle Twitching disappeared, the monitoring of sensory active nerve potential of median nerve waveform for the test group. record the two nerve conduction velocity, and latency valuesResult:1. changes of the blood pressure: compare the systolic and diastolic blood pressure, systolic blood pressure decreased 11.37%, 12.75% decline in diastolic blood pressure, mean arterial pressure in two groups were more than 60 mmHg, SpO₂ in two groups were more than 96%, there is no statistically significant difference between the two groups .2. There is no statistically significant difference between the two groups in conduction velocity (P>0.05)3. There is no statistically significant difference between the two groups in latency. (P>0.05)So, it showed that the two groups did not change significantly in nerve conduction velocity or latency, and that the application of non-depolarizing muscular relaxant vecuronium before and after the median nerve conduction velocity and latency had no significant changes.Conclusions: This study showed that nerve conduction velocity and latency did not change significantly by the application of vecuronium, through the speculation of the median nerve conduction velocity and the latency. So non-depolarizing muscular relaxant vecuronium may has no impact on monitoring nerve electrophysiology.