The Clinical Features In Young Male Patients With Coronary Heart Disease

OBJECTIVE:To elucidate the clinical features and risk factors in young male patients with coronary heart disease(CHD).METHODS:In 1st Affiliated Hospital of GuangXi Medical University, selected 315 male patients who had suffered from CHD first time from Jan 2005 to Aug 2007.All cases had undergone coronary angiography(CAG)and with entire clinical data.They were divided into two groups:The younger group (n=145,＜45yrs),the older group(n=170,≥65yrs).Comparing their risk factors,numbers of branch of coronary lesions and clinical features.The most risk factors include:total cholesterol(TC),low density lipoprotein cholesterol (LDL—C),high density lipoprotein cholesterol(HDL—C),triglyceride (TG),smoking,drinking,hypertension,diabetes mellitus,family history of cardiovascular disease.RESULTS:(1)The younger group had higher rate of smoking(72.4%: 40.0%,P＜0.01);But had lower rate of hypertension,diabetes mellitus compared with the older group(23.4%:69.4%,P＜0.01;11.0%:35.3%,P＜0.01).(2)The younger group had higher levels of triglyceride(TG)(2.31±1.66mmol/l:1.81±1.05mmol/l,P＜0.05);there were not different in TC,LDL—C,HDL—C between the two groups.(3)The younger patients had the higher proportion of one risk factor than the older patients(31.0%:12.4%, P＜0.01),The younger patients had the lower proportion of three risk factors than the older patients(12.4%:26.5%,P＜0.01),The younger patients had the lower proportion of more than four risk factors than the older patients(8.3%: 17.1%,P＜0.01).There were not difference in the proportion of zero risk factor and two risk factor between the two groups.(4)The younger group had the higher proportion of single coronary artery lesions than the older male patients (53.8%:31.8%,P＜0.01);The younger had lower proportion of the multiple branch lesions(13.1%:32.3%,P＜0.01);there were not difference in the proportion of zero branch lesion and two branch lesions between the two groups. The number of vessel disease increased significantly with the number of risk factors increased.(5)The younger group had higher morbidity of acute myocardial infarction(69.0%:48.8%,P＜0.01);lower morbidity of stable angina than the older group(6.2%:27.1%,P＜0.01).There were no difference of the unstable angina between the two groups.CONCLUSION:Smoking is the major risk factor for coronary heart disease of young man.High level of triglyceride is one of the important risk factors.The young male patients with CHD have higher morbidity of acute myocardial infarction.Most of the young male patients are single vessel disease. The number of vessel disease increased significantly with the number of risk factors increased.