The Multiplicity Of CyclinD1 In Breast Cancer

Objective To investigate the expression of CyclinD1 in the specimen of breast cancer and its correlation with pathologic staging, metastases of lymph nodes, the expression of estrogen receptor and anti-oncogene p53 in breast cancer. The comparison of the expression of CyclinD1 before and after chemotherapy is to reveal the relationship between the expression of CyclinD1 and the generation, development, prognosis of breast cancer, which enables it become a new diagnostic predictor and therapeutic target.Methods The expression of cyclinD1,ER and P53 was detected through Elivision plus immunohistochemical staining method in the breast cancer, and the results were analyzed with correlative clinical information. The statistical software SAS 6.12 was used to analyze the experimental results by extended Mantel-Haenasel statistical method.Results The expression of CyclinD1 was high in breast cancer and it increased following the staging and progression. It intimately correlated with the metastases of lymph nodes and the expression of estrogen receptor and anti-oncogene p53, whereas it had no correlation with the number of metastatic lymph nodes. The expression of CyclinD1 in the specimen of breast cancer decreased obviously after chemotherapy.Conclusion The expression of CyclinD1 is associated with the generation and development of breast cancer. It is an early affair, but its increase doesn't imply bad prognosis. Separate effect may exist between CyclinD1 and estrogen receptor. Through possible interaction CyclinD1 and anti-oncogene p53 participate together in the generation of breast cancer. The obvious decrease of the expression of CyclinD1 after chemotherapy suggests breast cancer could be treated by the treatment to decrease the expression of cyclinD1. CyclinD1 may become a new predictor marker in the diagnosis and treatment of breast cancer.