The Expression And Significance Of HIF-1α And E-cadherin In Primary Hepatic Cellular Carcinoma (PHCC) Tissues

Objective: To investigate the expression of HIF-1a and E-cadherin in primary hepatic cellular carcinoma(PHCC) tissues. Trough this experiment,we purpose to discuss its contribution in development of PHCC and raise morphology foundation for clinical study of PHCC.Methods: primary hepatic cellular carcinoma(PHCC) specimens were procured from 42 patients,with 8 cases of normal liver tissue being control group. HIF-1a and E - cadherin levels were assessed by immunohistochemical method. On the other hand,we analyzed the image by mean optical density.Result: The level of positive HIF-1αimmunostaining in PHCC is higher than in nomal liver tissue (P<0.01), and The level of positive E—cadherin immunostaining in PHCC is lower than in nomal liver tissue (P<0.05). We could find the expression of HIF-1a has relation with the expression of E-cadherin in PHCC with high differentiation (P<0.01) , but not in low differentiation group.Conclusions: The level of positive HIF-1aimmunostaining in PHCC is higher than in nomal liver tissue. The level of positive E—cadherin immunostaining in PHCC is lower than in nomal liver tissue HIF-1 alpha might repress E-cadherin expression asscociated with development of PHCC with high differentiation and increase the metastasizing ability of PHCC.