The Initial Study On The Correlation Of Periodontal Disease And Coronary Heart Disease

Objective:To explore the relationship between periodontal disease and coronary heart disease.We choose some CHD patients with periodontitis or without periodontitis in the study to make an epidemic survey.Meanwhile,some of them were taken blood samples to observe the level of TXB₂ and 6-K-PGF_1αthrough Radioimmunoassay.Methods:This research includes two parts.1.The epidemic survey.65 CHD patients referred for diagnostic coronary angiography were.assessed for periodontal disease.All the cases were performed clinical periodontal examination and serum tests,moreover,were analyzed the data.2.RIA test.20 subjects were chosen from the individuals above after adjusted by such factors as age,sex,race,weight,height,blood sugar and blood pressure.They were divided into 2 groups,one of which suffered from periodontitis(CP),and the second group was made of 10 CHD patients without periodontitis(C).Meanwhile,in our department,choose 10 patients suffering from periodontitis(P),and 10 was healthy volunteers(H).All of them underwent a comprehensive periodontal and serum examination.And then,blood samples were withdrawn and the TXB₂ and 6-K-PGF_1α level in serum samples were detected by Radioimmunoassay system.Results:1.The epidemic survey showed that the relationship between periodontal parameters and clinical serum parameters was that the loosen teeth, hypodontia(caused by periodontitis),residual root and crown,BI and CI had significantly positive correlations with the level of fibrinogen and leucocyte in serum., meanwhile all the periodontal parameters had no correlations with other serum parameters,such as GLU-AC,TC,TG,LDL,HDL,LP and SUA.2.The results of serum test showed that age,sex,BMI and smoking history were no significant differences(P＞0.05).One-way analysis of variance showed that the level of TXB₂,6-K-PGF_1α,FG,TG,GLU-AC and HDL among 4 groups had significant differences(P＜0.05).The level of TXB₂ in serum from the patients including CP,C and P group was higher than H subjects(P＜0.05).And so was observed for 6-K-PGF_1α level in serum.However,there were no significant differences among such groups as CP,C,and P(P＞0.05).The FG,TG and GLU-AC level in serum from CP and C group was higher than H group,and had significant differences(P＜0.04～0.00);P group was higher than H group,but there was no significant differences between P and H group. The HDL level in serum from H and P group was higher than CP and C group (P＜0.05～0.005),H group was higher than P group,but there was no significant differences.Conclusions:1.It was concluded from the epidemic survey that loosen teeth and periodontal infections may make microorganism and inner toxin in the oral cavity into the blood and lymph vessels,which may offer the opportunity for systemic infections,and may also increase the level of fibrinogen and leucocyte in the serum. On the other hand,the inner toxin may make the change of mechanism of blood coagulation and make the degeneration of platelets.If coronary artery is involved,it may be spasmodical.Besides,under the function of micro-blood coagulation,the coronary heart disease may occur.2.TXB₂ and 6-K-PGF_1αmay be important mediator in the initiation and progression of coronary heart disease and periodontitis,and contribute to the correlation between CHD and periodontal disease.3.The FG,TG and GLU-AC level in serum were higher in C and P group than in CP and H group;the level of HDL in C and P group was lower than in CP and H group which may indicate that periodontitis may have close correlation with coronary heart disease.4.From above,we can conclude that periodontal disease may be one of dangerous factors of coronary heart disease.