Research On The Correlation Between Serum Interleukin-6,Fasting Blood Glucose And Coronary Heart Disease And Adverse Cardiovascular Events

Objective: Explore the relationship between levels of interleukin-6(IL-6)and fasting blood glucose(FPG)with the severity and number of coronary artery stenosis,clinical classification of CHD,and the incidence of major adverse cardiovascular events(MACE)in a population with coronary heart disease(CHD)..Methods: Collect 72 CHD patients who visited the Fifth Affiliated Hospital of Xinjiang Medical University from September2020 to October 2020 and completed coronary angiography examinations,including stable angina(34 cases),unstable angina(24 cases),and acute myocardial infarction(14cases);28 healthy individuals admitted to the hospital during the same period were selected as the control group.Further grouping of CHD patients based on coronary angiography results and Gensini score.Compare the levels of serum IL-6 and FPG between each group,and analyze the correlation between them and CHD;Follow up was conducted on the subjects at 6,12,18,and 24 months after discharge to evaluate the relationship between serum IL-6 and FPG levels and cardiovascular adverse events.Results: Serum IL-6 level was positively correlated with clinical classification of coronary heart disease(r=0.345,P<0.001)and Gensini score(r= 0.253,P=0.011).FPG was positively correlated with clinical classification of coronary heart disease(r=0.315,P=0.001),number of coronary artery lesions(r= 0.217,P=0.030)and Gensini score(r=0.226,P=0.024).Cox regression analysis showed that increased serum IL-6 level was an independent risk factor for adverse cardiovascular outcomes(HR=1.024,95%Cl1.002～1.047,P=0.034),but serum FPG level was not significantly correlated with adverse cardiovascular outcomes.The incidence of complex endpoint events in serum high level IL-6 group(IL-6≥43.37ng/L).Conclusion:l.The levels of serum IL-6 and FPG are positively correlated with the degree of CHD;High serum IL-6 levels are positively correlated with poor cardiovascular prognosis,and detecting serum IL-6 levels has predictive value for the risk of MACE.