The Effect Of The Temozolomide In Exclusively Chemotherapy/in Radio-Chemotherapy Combined Treatmeng For The Intracal Glioblastoma After Operation

Objective:To observe the clinical effect of temozolomide in chemotherapy only/in radio-chemotherapy combined treatment for intracal glioblastoma after operation.Methods:From Spring 2007 to Spring 2008,35 eligile patients were randomised to divided in three groups.One group did not accept any therapy,one groups accept exclusively chemotherapy,one groups accept radio-chemotherapy combined treatment.TMZ was administered according to the body area. Radiotherapy project is routine dissection 60Gy/30 times.Meantime clinical experience should be performed every a month,and contrast enhanced CT scan or GD-MRI was performed to evaluate image-based progression comparing with the image before chemotherapy.We evaluate the therapeutic efficacy according to the imageology and clinical functional changes after chemotherapy. Results:3 month after chemotherapy.the progression to survival rate of the blanck control group and the chemotherapy group is separately 14.29%,66.67%(P＜0.05)according to the imageology.Meantime,the effective power of the exclusively chemotherapy group and the radio-chemotherapy group is separately 16.67%,66.67%(P＜0.05).the improvement rate of clinical functional status 41.67%。Conclusion:The chemotherapy application of temozolomide in Intracal spongioblastoma can delay the generation and recrudescence of tumor,it also can improve the clinical function.so it is an effective method of reducing the post-operation recrudescence and elevating the living quality The effect of radio-chemotherapy combined treatment is better than exclusively chemotherapy.