| ObjectiveTo assess protein expression levels of heparanase and basic fibroblast growth factor(bFGF) and the relation between their expressionand biological factors in human gastric carcinoma.MethodsA total of 80 paraffin-embedded gastric cancer and 20 normal specimens were studied by immunohistochemisty to evaluate the protein expression status of heparanase and bFGF. The relation was analyzed among the protein expression and age, sex, TNM stage, cell differentiation, invasion depth, lymphatic metastasis .ResultsImmunohistochemistry showed that 49 specimens were heparanase positive and 52 ones were bFGF positive among 80 cancer specimens. Both human heparanase and bFGF were highly expressed in cancer cell in contrast to none expression in normal tissue . Expression was in both cytoplasm and membranous. The agreement between heparanase and bFGF expression was significant. A significant correlation was found between the expression of either protein and cell differentiation ,TNM stage, invasion deapth, lymphatic metastasis.ConclusionBoth heparanase and bFGF were highly expressed in colorectal cancer .They may play important roles in tumor invasion, metastasis and angiogenesis.
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