Study On The Relationship Between Vitamin D Receptor And Apolipoprotein E Gene Polymorphism And Urinary Stone Disease Of Chinese Uygur In South XinJiang

Objective:1. To elucidate the relatonship between vitamin D receptor and urinary stone disease of Chinese uygur in XinJiang South.2. To elucidate the relatonship between apolipoprotein (Apo) E gene polymerphism and urinary stone disease of Chinese uygur in XinJiang South.3. To elucidate the relatonship between vitamin D receptor and apolipoprotein E gene polymerphism and urinary stone disease of Chinese uygur in XinJiang South.Methods: 90 Urinary Stone Disease patients and 90 normal controls were included. Polymerase chain reaction (PCR) and restriction endonuclease analysis were used to detect Taq1,Apa1,Fok1 of ditamin D receptor gene type and Apo E geno type. The results were analyzed using x2 test.Results:1. The genotype frequency distribution of Fok1 allele polymorphism in the urinary stone disease patients was significantly different from that in the control group(χ2=8.28,p<0.001). The frequency of the FF genotype in the patients(43%) was higher than in the control group(30%).2. The genotype frequency distribution of Apa1 allele polymorphism in the urinary stone disease patients was significantly different from that in the control group too (χ2=14.22,p<0.001). The frequency of the Aa genetype in the patients(63.3%) was higher than in the control group(35.6%).3. The genotype frequency distribution of Taq1 allele polymorphism in the urinary stone disease patients was npt significantly different from that in the control group (χ2=14.22,p<0.001). The frequency of the Aa genetype in the patients(63.3%) was higher than in the control group(35.6%).4. The frequency of E3/4 gene type in uronary stone disease patients was significantly higher than that in the control group (χ2=12.96, p<0.001)). The frequency of E4 allele in urinary stone disease patients was also significantly higher than that in the control group (χ2=6.61, p<0.025).5. The frequency of FF/ Aa gene type in uronary stone disease patients was significantly higher than that in the control group (χ2=12.28,p<0.001). The frequency of Ff/aa genetype in uronary stone disease patients was significantly higher than that in the control group too(χ2=12.3,p<0.001). 6. The frequency of FF/ Aa gene type in uronary stone disease patients was significantly higher than that in the control group (χ2=14.1,p<0.001). The frequency of Ff/aa genetype in uronary stone disease patients was significantly higher than that in the control group too(χ2=7.74,p<0.05).Conclusion:The VDR genotypes and ApoE genotypes may be used as genetic markers in prediction their risk of developing urinary stone disease of Chinese uygur in XinJiang South.